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Jul 18, 2022
"Repurposing Siddha mercurial drug for mild to moderate COVID-19 - Case series and exploration of its chemical profile" was publisehd in Journal of Ayurveda Integrative Medicine. Vajra kandi maathirai (VKM) is a mercury based traditional Siddha drug used to treat various types of fevers and inflammatory diseases. A family with 5 members age ranges between 13 to 77, both male and females, one with preexisting renal impairment, SARS CoV-2 positive with mild to moderate category were treated with VKM. The CT chest of the father showed multiple patches of ground-glass opacities in all the lobes of both the lungs and crazy paving pattern in right lower lobe with CT severity score of 11. All of them were treated with VKM along with the specific dietary practice. With the first dose, the oxygen saturation was improved. Within 3 days of therapy, all symptoms (fever, body pain, cough, and loss of taste) were normalized and renders the Real-Time RT PCR negative for COVID-19. There was no observed side effects and damage to the renal and liver. VKM was subjected for the chemical profiling using GCMS for organic and ICP-MS for inorganics respectively. The drug contains 22% of mercury along with a 9-Octadecenoic acid-(E), 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl) and 9,12-Octadecadienoic acid (Z,Z)- as major organic compounds. The therapeutic benefit is a collective action of the inorganics and phytocompounds. https://pubmed.ncbi.nlm.nih.gov/34226805/
